Following the 2022 Monkeypox Outbreak, during the course of May of that year, it was reported that several players were naming their plague 'Monkeypox'. became one of the most downloaded iOS video games in Colombia during the country's confinement, according to Adsmovil. The game increased in download ranking in the South Korea's Apple App Store, following the outbreak of MERS in the country during 2015, as new cases were reported in the summer of that year. Another example would be that there was an increase in players when the Ebola outbreak started in 2015. was #1 in Japan, it was correlated with outbreaks of bad flu. The game has experienced popularity increases depending on disease outbreaks, an example would be when Plague Inc.